This kit will fill in some missing pieces for those who have particularly difficult cases. The super challenges will push the pathways just a bit harder to reveal some weaknesses that may not show up without a bit of pressure. In addition, we added some testers for Pyroluria, the Citric acid cycle and other pathways outside of the methylation pathways. Using the HLA and Major histocompatibility vials will uncover hidden immune reactions to various substances. This can help with those “hidden” health issues that are truly confounding! Price includes shipping.